CAD Exchanger uses a right-handed coordinate system having the OZ as an up axis. The recent CAD Exchanger versions have the "Use OY as Up axis" option. If it's enabled, the exported model will be re-oriented accordingly. It's accessible through Menu > Settings > Export Settings, and currently available for the following formats: 3DPDF, Collada, FBX, gLTF, OBJ, U3D, USD.